Overview
Research in the Graveley lab is primarily focused on the regulation of alternative splicing and small RNA mediated gene regulation. These are fascinating and extraordinarily important mechanisms by which genes can be regulated. Our long-term goals are to understand how these processes are regulated at a mechanistic level and to understand the logic of these processes in significant biological settings. To achieve these goals, we strive to think outside the box to creatively attack the problems being addressed using a wide variety of approaches that include biochemistry, genetics, imaging, deep sequencing, microarrays, large-scale RNAi screening and bioinformatics.
Featured Publications
Smibert P, Miura P, Westholm JO, Shenker S, May G, Duff MO, Zhang D, Eads BD, Carlson J, Brown JB, Eisman RC, Andrews J, Kaufman T, Cherbas P, Celniker SE, Graveley BR, Lai EC. (2012) Global Patterns of Tissue-Specific Alternative Polyadenylation in Drosophila. Cell Reports, 1:277-289. doi:10.1016/j.celrep.2012.01.001. Cell Reports Website
Hale CR, Majumdar S, Elmore J, Pfister N, Compton M, Olson S, Resch AM, Glover CVCIII, Graveley BR, Terns RM, Terns MP. (2012) Essential features and rational design of CRISPR RNAs that function with the Cas RAMP mosdule complex to cleave RNAs. Mol. Cell, doi:10.1016/j.molcel.2011.10.023. PubMed
Graveley et al. (2011) The developmental transcriptome of Drosophila melanogaster. Nature. 471:473-9. PubMed
McManus CJ, Duff MO, Eipper-Mains J, Graveley BR. (2010) Global analysis of trans-splicing in Drosophila. Proc Natl Acad Sci U S A 107:12975-9.PubMed
Recent News
4/5/12
Congrats to Alissa Resh and former lab memebers Dasaradhi Palakodeti, Yi-Chien Lu, and Misha Horowitz for their publication in PLoS ONE on the transcriptome analysis of planarian stem cells.
2/23/12
Congrats to Mike Duff and Gemma May for their publication in Cell Reports on a genome-wide analysis of polyadenylation in Drosophila, which was a collaboration with Eric Lai and Sue Celniker's labs and other members of the modENCODE consortium
1/10/12
Welcome to the newest members of the lab, Postdoctoral fellows Alex Plocik and Vidya Balagopal and Research Assistant LiJun Zhan.
1/4/12
Congrats to Sara Olson and Alissa Resch for their publication in Molecular Cell on CRISPR RNAs, which was a collaboration with Mike and Becky Terns
Funding
Work in our lab is funded by grants from the NIH and the Connecticut Stem Cell Research Fund.